Womb transplants hailed as success in pioneering Swedish project
Ethical
approval given for operations as part of local clinical trial following
procedure’s success in Sweden.
Following the birth of a baby boy last year following a successful procedure in Sweden, Imperial
College London has granted ethical approval for 10 transplants. The first
British baby born following a womb transplant could arrive as soon as late 2017
or 2018.
More than 100 women have been identified as potential
recipients of transplants for a team of surgeons to be led by Dr Richard Smith.
About one in 5,000 women – or 50,000 of childbearing age in
the UK – were born without a womb, while some cancer sufferers have had theirs
removed.
Smith said the technique would offer hope to women who could
only have children through adoption or surrogacy. The consultant gynaecologist
at the Queen Charlotte’s and Chelsea hospital, who has been working on the
project for almost 20 years, said he was “really, really pleased” to obtain
ethical approval for the transplants.
“For many couples, childlessness is a disaster. Infertility
is a difficult thing to treat for these women,” he said.
“Surrogacy is an option but it does not answer the deep
desire that women have to carry their own baby. For a woman to carry her own
baby – that has to be a wonderful thing.”
To take part in the trial a woman must be aged between 25
and 38, have functioning ovaries and their own eggs, a long-term partner and be
a healthy weight. Only a third of the 300 women who approached the Womb
Transplant UKteam
met the criteria.
Before the trial starts, embryos will be created and frozen
using each woman’s eggs and sperm from her partner. They will then undergo a
six-hour operation to receive a womb from a donor who is classed as braindead
but who has been kept alive.
Smith said using deceased donors reflected the complexities
of the operation.
“Donor retrieval is a bigger operation than transplanting
the uterus into the recipient,” the surgeon said. “We don’t want to subject a
live donor to that operation.”
Organ donor coordinators have suggested that about five
wombs annually could be made available.
After 12 months on immunosuppressant drugs and close
monitoring, each woman will be implanted with one of her embryos, with the hope
of achieving a successful pregnancy.
A baby would be delivered by caesarean section
to prevent the donor womb suffering the trauma of labour.
Six months after giving
birth, each woman can try for another child, or the womb will be removed. That
would minimise the risk of keeping women on immunosuppressant drugs for the
rest of their lives.
However, the trial needs
to raise £500,000 before any operations can take place.
“I’ve always been an
enormous optimist,” Smith said. “The project has run with no money from the
start. Somehow or other, somebody has always turned up and given us enough
money to keep it going.”
Just over £40,000 has
been donated to the Womb Transplant UK project and contributions can be made
here.
A 36-year-old Swedish
woman gave birth to a baby boy in September 2014 after receiving a
donor womb from a 61-year-old family friend who had given birth to two sons.
She and her partner – both competitive athletes – named the baby Vincent, which
means “to win” in Latin.
“As soon as I felt this
perfect baby boy on my chest, I had tears of happiness and enormous relief,”
the mother said. She had been told at the age of 15 that she did not have a
womb.
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